Mirabegron

Mirabegron is a medication used to treat overactive bladder. It may take 8 weeks or longer before you feel the full benefit of this medication.

Mirabegron Overview

Reviewed: July 24, 2012
Updated: 

Mirabegron is a prescription medication used alone or in combination with solifenacin to treat overactive bladder.

Mirabegron belongs to a group of drugs called beta-3 adrenergic agonists, which help the bladder muscles to relax.

This medication comes in tablet form and is taken once a day, with water. Mirabegron can be taken with or without food.

Common side effects include increased blood pressure, cold symptoms, and headache.

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Mirabegron Cautionary Labels

precautionsprecautionsprecautions

Uses of Mirabegron

Mirabegron is a prescription medication used to treat adults with the symptoms of overactive bladder.

This medication can be used alone or in combination with solifenacin. Symptoms of overactive bladder include:

  • urinary frequency (urinating often)
  • urinary urgency (a strong need to urinate right away)
  • urinary incontinence (leakage)

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Mirabegron Brand Names

Mirabegron may be found in some form under the following brand names:

Mirabegron Drug Class

Mirabegron is part of the drug class:

Side Effects of Mirabegron

Mirabegron may cause serious side effects. See Drug Precautions. 

The most common side effects include:

  • increased blood pressure
  • common cold symptoms (nasopharyngitis)
  • urinary tract infection
  • headache

Other side effects that may occur when mirabegron and solifenacin are taken together include:

  • dry mouth
  • constipation
  • fast heart rate

Tell your doctor if you have any side effect that bothers you or that does not go away or if you have hives, skin rash or itching while taking mirabegron.

These are not all the possible side effects of mirabegron. For more information, ask your doctor or pharmacist.

Mirabegron Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Mirabegron may affect the way other medicines work, and other medicines may affect how mirabegron works.

  • Medications metabolized through CYP2D6 such as metoprolol and desipramine
  • Digoxin (Lanoxin)

Tell your doctor if you take:

  • thioridazine (Mellaril or Mellaril-S)
  • flecainide (Tambocor)
  • propafenone (Rythmol)
  • digoxin (Lanoxin)

This is not a complete list of mirabegron drug interactions. Ask your doctor or pharmacist for more information.

Mirabegron Precautions

Mirabegron may cause serious side effects including:

  • increased blood pressure. Myrbetriq may cause your blood pressure to increase or make your blood pressure worse if you have a history of high blood pressure. It is recommended your doctor check your blood pressure while you are taking Myrbetriq, particularly if you have a history of high blood pressure. 
  • inability to empty your bladder (urinary retention). Urinary retention can happen if you have bladder outlet obstruction (BOO) or if you taking other medicines to treat overactive bladder. Talk to your doctor if you are unsure if this applies to you. Tell your doctor right away if you are unable to empty your bladder.
  • angioedema. This medication may cause an allergic reaction with swelling of the lips, face, tongue, throat with or without difficulty breathing. If this occurs, stop using this medication and call your doctor right away.
  • interactions with medications metabolized through CYP2D6 such as metoprolol and desipramine. Your doctor will monitor you closely if you are taking both medications. 

Do not take mirabegron if you are allergic to it. 

 

 

Mirabegron Food Interactions

Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of mirabegron there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before you take mirabegron, tell your doctor if you:

  • are allergic to this medication or to any of its ingredients
  • have liver problems
  • have kidney problems
  • have very high uncontrolled blood pressure
  • have trouble emptying your bladder or you have a weak urine stream
  • are pregnant or plan to become pregnant. It is not known if mirabegron will harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant.
  • are breastfeeding or plan to breastfeed. It is not known if mirabegron passes into your breast milk. You and your doctor should decide if you will take mirabegron or breastfeed. You should not do both.

Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Mirabegron and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

There are no studies with the use of this medication in pregnant women in order to determine the drug-associated risk for birth defects or miscarriage.

In animal studies, pregnant animals were given this medication, in large amounts, and had some babies born with problems. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

Mirabegron and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed. 

No studies have been conducted to assess the impact of mirabegron on milk production in humans, its presence in human breast milk, or its effects on the breast-fed child. Because mirabegron is predicted to be excreted in human milk and because of the potential for serious adverse reactions in nursing infants, talk to your doctor about whether you should discontinue nursing or discontinue taking this medicine.

Mirabegron Usage

Take mirabegron exactly as your doctor tells you to take it.

  • You should take 1 mirabegron tablet once a day, with water. Swallow the tablet whole. Never crush or chew it.
  • You can take mirabegron with or without food.
  • If you take this medication in combination with solifenacin, take them together once a day, with or without food. 
  • If you miss a dose of mirabegron, begin taking it again the next day. Do not take 2 doses of mirabegron the same day.

Mirabegron Dosage

Take mirabegron exactly as prescribed by your doctor. Follow the directions on your prescription label carefully. 

The recommended starting dose of Myrbetriq (mirabegron) is 25 mg once daily with or without food. Myrbetriq 25 mg is effective within 8 weeks. The dose may be increased to 50 mg once daily, if needed.

Mirabegron may be given in combination with solifenacin. In this case, you will take both together once a day. 

For those with severe kidney disease or moderate liver disease, the dose should not exceed 25 mg once daily. 

 

Mirabegron Overdose

If you take too much mirabegron, call your local Poison Control Center or seek emergency medical attention right away.

Other Requirements

  • Store mirabegron at room temperature, between 59˚F to 86˚F (15˚C to 30˚C). Keep the bottle closed.
  • Safely throw away medicine that is out of date or no longer needed.
  • Keep mirabegron and all medicines out of the reach of children.