Nocdurna is used in adults who wake up at least 2 times during the night to urinate due to a condition called nocturnal polyuria. Avoid drinks containing caffeine and alcohol before bedtime.
Nocdurna is a prescription medication used to treat excessive nighttime urination.
Nocdurna imitates a natural hormone in your body called vasopressin. This hormone helps the kidneys produce less water at night. If you don’t have enough vasopressin, your kidneys may release too much water at night, causing frequent nighttime urination.
Nocdurna comes as a tablet that dissolves quickly under your tongue—without water. It is taken once a day 1 hour before bedtime. Keep the tablet under the tongue until it has fully dissolved.
Common side effects include dry mouth, low blood sodium, and dizziness. Do not drive or operate heavy machinery until you know how Nocdurna affects you.
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Nocdurna Cautionary Labels
Uses of Nocdurna
Nocdurna is a prescription medicine used in adults who wake up at least 2 times during the night to urinate due to a condition called nocturnal polyuria. Nocturnal polyuria is a condition where your body makes too much urine at night.
There are other conditions that could cause you to wake up during the night to urinate. Nocdurna is only approved for the treatment of nocturnal polyuria.
Your doctor should have you measure your urine and the times that you urinate for 24 hours to determine if you have nocturnal polyuria, if you have not already done this.
It is not known if Nocdurna is safe and effective in children.
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
Nocdurna Drug Class
Nocdurna is part of the drug class:
Side Effects of Nocdurna
Serious side effects have been reported with Nocdurna. See the “Nocdurna Precautions” section.
Common side effects of Nocdurna include the following:
- dry mouth
- low blood sodium
This is not a complete list of Nocdurna side effects. Ask your doctor or pharmacist for more information.
Tell your doctor if you have any side effects that bother you or that do not go away.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:
- loop or thiazide diuretics such as
- steroids such as prednisone (Cortan, Deltasone, Orasone, Sterapred), budesonide (Entocort), dexamethasone (Decadron), triamcinolone (Kenacort, Aristocort), flunisolide (AeroBid, Aerospan), ciclesonide (Alvesco), mometasone (Asmanex, Dulera), fluticasone (Flovent), methylprednisolone (Medrol, Solu-Medrol), fludrocortisone (Florinef), and hydrocortisone (Cortef, Cortril, Hydrocortone)
- tricyclic antidepressants such as trimipramine (Surmontil), amitriptyline (Elavil), nortriptyline (Pamelor, Aventyl), protriptyline (Vivactil), and clomipramine (Anafranil)
- selective serotonin reuptake inhibitors (SSRIs) such as escitalopram (Lexapro), sertraline (Zoloft), citalopram (Celexa), vilazodone (Viibryd), paroxetine (Paxil), fluoxetine (Prozac, Sarafem), and fluvoxamine (Luvox)
- sulfonylureas such as chlorpropamide (Diabinese), glyburide (DiaBeta, Micronase), glimepiride (Amaryl), and glipizide (Glucotrol)
- nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, or aspirin
- opioid pain relieving medications including tramadol (Ultram), morphine (MS Contin), hydromorphone (Dilaudid), oxymorphone (Opana), oxycodone (Oxycontin), hydrocodone (Vantrela), fentanyl (Duragesic), codeine, meperidine (Demerol)
This is not a complete list of Nocdurna drug interactions. Ask your doctor or pharmacist for more information.
Serious side effects have been reported with Nocdurna including the following:
- Low levels of salt (sodium) in your blood (hyponatremia). Low levels of salt in your blood is a serious side effect of Nocdurna that may be life threatening, causing seizures, coma, trouble breathing or death, if not treated early. Stop taking Nocdurna and call your healthcare provider if you have any of the following symptoms of low salt levels in your blood:
- nausea or vomiting
- feeling restless
- tiredness (fatigue)
- muscle cramps
- change in your mental condition such as hallucinations, confusion, decreased awareness or alertness
You should not take Nocdurna if you are at risk for very low salt levels in your blood, for example, if you drink a lot of fluid, have illnesses that can cause you to have fluid or body salt (electrolyte) imbalances, if you take a certain type of “water-pill” called a loop diuretic or take glucocorticoids including inhaled steroids.
Tell your healthcare provider if you have a fever, infection, or diarrhea while taking Nocdurna as these can cause you to have fluid or body salt (electrolyte) imbalance. Your healthcare provider may tell you not to take Nocdurna while you have these symptoms.
Your healthcare provider should check your blood salt levels:
- before you start or restart taking Nocdurna.
- within the first week after you start Nocdurna
- 1 month after you start Nocdurna.
- every so often as told to you by your healthcare provider, with testing more often if you are already at risk for low salt levels, for example if you are 65 years or older or take certain medicines that increase your risk of low salt levels.
Do not take Nocdurna if you:
- have or have had low salt levels in your blood.
- are thirsty much of the time and drink large amounts of fluids (polydipsia).
- are taking a type of water pill called a loop-diuretic.
- are taking a glucocorticoid (steroid) medicine, including an inhaled glucocorticoid (steroid) medicine.
- have moderate or severe kidney disease.
- have or may have a condition called syndrome of inappropriate antidiuretic hormone (SIADH) secretion.
- have an illness that can cause you to have low levels of fluid or electrolytes in your blood such as vomiting, diarrhea, an infection, or a kidney problem that causes you to have low levels of salt.
- have a heart condition called heart failure.
- have high blood pressure that is not controlled.
- are allergic to any ingredient in Nocdurna tablets
Talk to your healthcare provider before you take Nocdurna if you have any of these conditions or take any of these medicines.
Nocdurna Food Interactions
Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Nocdurna, there are no specific foods that you must exclude from your diet when receiving this medication.
Before taking Nocdurna, tell your healthcare provider about all of your medical conditions, including if you:
- are at risk for low salt levels in your blood.
- currently have vomiting, diarrhea, fever or an infection.
- have any heart or kidney problems.
- have high blood pressure.
- have increased pressure in your brain (increased intracranial pressure).
- have a history of not being able to empty your bladder all the way (urinary retention).
- are pregnant or planning to become pregnant. It is not known if Nocdurna can harm your unborn baby. Nocdurna is not recommended to treat normal symptoms of pregnancy that cause pregnant women to urinate often at night.
- are breastfeeding or plan to breastfeed. Desmopressin, an ingredient in Nocdurna, passes into breastmilk. Talk to your healthcare provider about the best way to feed your baby if you take Nocdurna.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Using Nocdurna with certain medicines may cause serious side effects. Do not start taking any new medicines until you talk to your healthcare provider.
Especially tell your healthcare provider if you take a:
- water pill (diuretic).
- glucocorticoid (steroid) medicine, including an inhaled glucocorticoid (steroid) medicine.
- your doctor should stop your treatment with Nocdurna for a period of time while you are taking and after you stop taking an oral or inhaled glucocorticoid (steroid) medicine
- medicine used to treat depression called a tricyclic antidepressant or selective serotonin reuptake inhibitor (SSRI).
- medicine used to treat mood disorders, such as schizophrenia or bipolar disorder called chlorpromazine.
- medicine used to treat seizures, nerve pain, or bipolar disorder called carbamazepine.
- non-steroidal anti-inflammatory medicine (NSAID).
Ask your healthcare provider or pharmacist if you are not sure if your medicine is one that is listed above.
Tell your healthcare provider if you have fever, infection, or diarrhea while taking Nocdurna as these can cause you to have fluid or body salt (electrolyte) imbalance. Your healthcare provider may tell you not to take Nocdurna while you have these symptoms.
Nocdurna and Pregnancy
Tell your doctor if you are pregnant or plan to become pregnant.
Nocdurna is not recommended to treat nocturnal polyuria in pregnant women. Nocturnal polyuria during pregnancy is usually a result of normal changes in the body that do not require treatment with Nocdurna.
Nocdurna and Lactation
Tell your doctor if you are breastfeeding or plan to breastfeed.
Nocdurna has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from Nocdurna, a choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered.
Take Nocdurna exactly as prescribed.
You should take Nocdurna 1 time each day, 1 hour before bedtime without water.
When you are ready to take your dose of Nocdurna:
- Place the tablet under your tongue 1 hour before bedtime. Leave the tablet under your tongue until it dissolves.
- Empty your bladder just before bedtime.
While taking Nocdurna, you should limit the amount of water or liquids you drink from 1 hour before taking Nocdurna and until 8 hours after. You may have serious side effects if you drink too much liquid.
You should avoid drinks containing caffeine and alcohol before bedtime as this can cause your body to make more urine.
Do not take more Nocdurna than prescribed for you. If you take too much Nocdurna, call your healthcare provider right away or get emergency treatment.
Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.
The dose your doctor recommends may be based on the following:
The recommended dose of Nocdurna is 27.7 mcg once daily 1 hour before bedtime for women and 55.3 mcg once daily 1 hour before bedtime for men.
If you take too much Nocdurna, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.
- Store Nocdurna at room temperature between 68° to 77oF (20° to 25oC).
- Keep Nocdurna in its blister pack until it is time to take it, in order to protect it from moisture and light.
- Keep Nocdurna and all medicines out of the reach of children.
Nocdurna FDA Warning
Nocdurna can cause hyponatremia. Severe hyponatremia can be life-threatening, leading to seizures, coma, respiratory arrest, or death.
Nocdurna is contraindicated in patients at increased risk of severe hyponatremia, such as patients with excessive fluid intake, illnesses that can cause fluid or electrolyte imbalances, and in those using loop diuretics or systemic or inhaled glucocorticoids.
Ensure the serum sodium concentration is normal before starting or resuming Nocdurna. Measure serum sodium within 7 days and approximately 1 month after initiating therapy, and periodically during treatment. More frequently monitor serum sodium in patients 65 years of age and older and in patients at increased risk of hyponatremia.
If hyponatremia occurs, Nocdurna may need to be temporarily or permanently discontinued.