Viibryd treats depression. It may take several weeks before you feel the full benefit of this medication. Take Viibryd with food.

Viibryd Overview


Viibryd is a prescription medication used to treat depression. Viibryd belongs to a group of drugs called antidepressants. It works by altering chemicals in the brain to help maintain mental balance.

This medication comes in tablet form and is usually taken once daily, with food.

Common side effects of Viibryd include diarrhea, nausea, and vomiting.

How was your experience with Viibryd?

First, a little about yourself

Tell us about yourself in a few words?

What tips would you provide a friend before taking Viibryd?

What are you taking Viibryd for?

Choose one
  • Other

How long have you been taking it?

Choose one
  • Less than a week
  • A couple weeks
  • A month or so
  • A few months
  • A year or so
  • Two years or more

How well did Viibryd work for you?

Did you experience many side effects while taking this drug?

How likely would you be to recommend Viibryd to a friend?

Pill Images

{{ }}
pill-image {{ }}
Color: {{ slide.color }} Shape: {{ slide.shape }} Size: {{ slide.size }} Score: {{ slide.score }} Imprint: {{ slide.imprint }}
{{ slide.number }} of {{ }}

Viibryd Cautionary Labels


Uses of Viibryd

Viibryd is a prescription medicine used to treat a certain type of depression called Major Depressive Disorder (MDD). 

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.


Viibryd Drug Class

Viibryd is part of the drug class:

Side Effects of Viibryd

Viibryd may cause serious side effects, including:

  • See "Drug Precautions".

Common side effects in people who take Viibryd include:

  • diarrhea
  • nausea or vomiting
  • trouble sleeping

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Viibryd. For more information, ask your healthcare provider or pharmacist.

Viibryd Interactions

Tell your healthcare provider about all the medicines that you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Viibryd and some medicines may interact with each other, may not work as well, or may cause serious side effects when taken together.

Especially tell your healthcare provider if you take:

  • triptans used to treat migraine headache
  • medicines used to treat mood, anxiety, psychotic or thought disorders, including tricyclics, lithium, SSRIs, SNRIs, buspirone, or antipsychotics
  • tramadol
  • over-the-counter supplements such as tryptophan or St. John’s Wort
  • nonsteroidal anti-inflammatory drugs (NSAIDS)
  • aspirin
  • warfarin (Coumadin, Jantoven)
  • mephenytoin (Mesantoin)
  • diuretics

Your healthcare provider or pharmacist can tell you if it is safe to take Viibryd with your other medicines. Do not start or stop any medicine while taking Viibryd without talking to your healthcare provider first.

Viibryd Precautions

Viibryd and other antidepressant medicines may cause serious side effects.

Call your healthcare provider right away if you have any of the following symptoms, or call 911 if there is an emergency:

  1. Suicidal thoughts or actions:
    • Viibryd and other antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, or young adults within the first few months of treatment or when the dose is changed.
    • Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions.
    • Watch for these changes and call your healthcare provider right away if you notice:
      • New or sudden changes in mood, behavior, actions, thoughts, or feelings, especially if severe.
      • Pay particular attention to such changes when Viibryd is started or when the dose is changed.

      Keep all follow-up visits with your healthcare provider and call between visits if you are worried about symptoms. 
      Call your healthcare provider right away if you have any of the following symptoms, especially if they are new, worse, or worry you:
      • attempts to commit suicide
      • acting on dangerous impulses
      • acting aggressive or violent
      • thoughts about suicide or dying
      • new or worse depression
      • new or worse anxiety or panic attacks
      • feeling agitated, restless, angry or irritable
      • trouble sleeping
      • an increase in activity or talking more than what is normal for you (mania)
      • other unusual changes in behavior or mood
  2. Serotonin Syndrome or Neuroleptic Malignant Syndrome-like reactions:
    • agitation, hallucinations, coma or other changes in mental status
    • coordination problems or muscle twitching (overactive reflexes)
    • fast heartbeat, high or low blood pressure
    • sweating or fever
    • nausea, vomiting, or diarrhea
    • muscle stiffness or tightness
  3. Abnormal bleeding: Viibryd and other antidepressant medicines may increase your risk of bleeding or bruising, especially if you take the blood thinner warfarin (Coumadin, Jantoven), a non-steroidal anti-inflammatory drug (NSAID), or aspirin.
  4. Seizures or convulsions.
  5. Manic episodes:
    • greatly increased energy
    • severe trouble sleeping
    • racing thoughts
    • reckless behavior
    • unusually grand ideas
    • excessive happiness or irritability
    • talking more or faster than usual
  6. Low salt (sodium) levels in the blood. 
    Elderly people may be at greater risk for this. Symptoms may include:
    • headache
    • weakness or feeling unsteady
    • confusion, problems concentrating or thinking or memory problems

Do not stop Viibryd without first talking to your healthcare provider. Stopping Viibryd suddenly may cause serious symptoms including:

  • anxiety, irritability, high or low mood, feeling restless or sleepy
  • headache, sweating, nausea, dizziness
  • electric shock-like sensations, tremor, confusion

Do not take Viibryd if you:

  • Take an monoamine oxidase inhibitor (MAOI). Ask your healthcare provider or pharmacist if you are not sure if you take an MAOI.
    People who take Viibryd close in time to taking an MAOI may have serious or even life-threatening side effects. Get medical help right away if you have any of these symptoms:
    • Do not take an MAOI within 14 days of stopping Viibryd.
    • Do not start Viibryd if you stopped taking an MAOI in the last 14 days.
    • high fever
    • uncontrolled muscle spasms
    • stiff muscles
    • rapid changes in heart rate or blood pressure
    • confusion
    • loss of consciousness (pass out)
  • Viibryd can cause sleepiness or may affect your ability to make decisions, think clearly, or react quickly. You should not drive, operate heavy machinery, or do other dangerous activities until you know how Viibryd affects you.
  • You should avoid drinking alcohol while taking Viibryd. 

Viibryd Food Interactions

Grapefruit and grapefruit juice may interact with Viibryd and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.

Inform MD

Before starting Viibryd, tell your healthcare provider if you:

  • have liver problems
  • have kidney problems
  • have or had seizures or convulsions
  • have bipolar disorder (manic depression) or mania
  • have low sodium levels in your blood
  • have or had bleeding problems
  • drink alcohol
  • have any other medical conditions
  • are pregnant or plan to become pregnant
  • are breastfeeding or plan to breastfeed

Tell your healthcare provider about all the medicines that you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Viibryd and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

This medication falls into category C. In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

Viibryd and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed. It is not known if Viibryd passes into breast milk. You and your healthcare provider should decide if you should take Viibryd while breastfeeding.

Viibryd Usage

  • Take Viibryd exactly as prescribed. Your healthcare provider may need to change the dose of Viibryd until it is the right dose for you.
  • Take Viibryd with food. Viibryd may not work as well if you take it on an empty stomach.
  • If you miss a dose of Viibryd, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Viibryd at the same.
  • If you take too much Viibryd, call your healthcare provider or poison control center right away, or get emergency treatment.

Viibryd Dosage

Take Viibryd exactly as directed by your doctor. Follow the directions on your prescription label carefully.

The recommended dose for Viibryd is 20 mg to 40 mg once daily, with food.

Viibryd should be gradually increased, starting with an initial dose of 10 mg once daily for 7 days, followed by 20 mg once daily for an additional 7 days, and then the dose may be increased to 40 mg once daily. 

Viibryd Overdose

If you take too much Viibryd, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

Other Requirements

  • Store Viibryd at room temperature (59°F to 86°F or 15°C to 30°C).
  • Keep Viibryd and all medicines out of the reach of children.

Viibryd FDA Warning


Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of Major Depressive Disorder (MDD) and other psychiatric disorders. Anyone considering the use of Viibryd or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Viibryd is not approved for use in pediatric patients.