Invokamet

Invokamet combines two medications to treat type 2 diabetes. Although Invokamet is not for weight loss, it may help you lose some weight.

Invokamet Overview

Reviewed: August 12, 2014
Updated: 

Invokamet is a prescription medication used to treat type 2 diabetes.

It is a single product containing 2 different medications: canagliflozin and metformin. Canagliflozin belongs to a group of drugs called sodium-glucose co-transporter 2 (SGLT2) inhibitors. SGLT2 inhibitors work by allowing the kidneys to get rid of more sugar by dumping it in the urine. Metformin belongs to a group of drugs called biguanides. Biguanides work by reducing the amount of sugar produced by the liver. Together, these medications work to lower blood sugars. 

This medication comes in a tablet form and is usually taken twice a day with food.

Common side effects of Invokamet include diarrhea, bloating, frequent urination, and thirst.

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Invokamet Cautionary Labels

precautionsprecautionsprecautionsprecautionsprecautionsprecautions

Uses of Invokamet

Invokamet is a prescription medication used to treat Type 2 Diabetes.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

Manufacturer

Invokamet Drug Class

Invokamet is part of the drug class:

Side Effects of Invokamet

Serious side effects have been reported with Invokamet. See the “Drug Precautions” section.

Common side effects of Invokamet include the following:

  • Frequent urination
  • Genital fungal infections (yeast infections)
  • Urinary tract infections (UTI)
  • Diarrhea
  • Flatulence (gas)
  • Bloating
  • Thirst

This is not a complete list of side effects. Ask your doctor or pharmacist for more information. Tell your doctor if you have any side effect that bothers you or that does not go away. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Invokamet Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • Alcohol
  • Pimozide
  • Diuretics such as
    • Acetazolamide (Diamox)
    • Amiloride (Midamor)
    • Bumetanide (Bumex)
    • Chlorothiazide (Diuril)
    • Chlorthalidone (Thalitone)
    • Ethacrynic acid (Edecrin)
    • Furosemide (Lasix)
    • Hydrochlorothiazide (Microzide, HCTZ)
    • Metolazone (Zaroxolyn)
    • Torsemide (Demadex)
    • Triamterene (Dyrenium, Dyazide, Maxzide)
  • Angiotensin-converting enzyme (ACE) blockers such as
    • Benazepril (Lotensin, Lotensin HCT)
    • Captopril (Capoten, Capozide)
    • Enalapril (Vasotec, Vaseretic)
    • Fosinopril (Monopril, Monopril HCT)
    • Lisinopril (Prinivil, Prinzide, Zestril, Zestoretic)
    • Moexipril (Univasc, Uniretic)
    • Quinapril (Accupril, Accuretic, Quinaretic)
    • Ramipril (Altace)
    • Trandolapril (Mavik, Tarka)
  • Angiotensin receptor II blockers such as
    • Azilsartan (Edarbi)
    • Candesartan (Atacand)
    • Irbesartan (Avapro)
    • Losartan (Cozaar)
    • Olmesartan (Benicar)
    • Telmisartan (Micardis, Twynsta)
    • Valsartan (Diovan)
  • Blood pressure medications such as
    • Potassium-sparing diuretics such as spironolactone (Aldactone), triamterene (Dyrenium), amiloride (Midamor)
    • Beta blockers such as metoprolol (Toprol XL, Lopressor), carvedilol (Coreg), bisoprolol (Zebeta), betaxolol (Kerlone), nebivolol (Bystolic), propranolol (Inderal)
    • Calcium channel blockers such as nifedipine (Adalat, Nifedical, Procardia), amlodipine (Norvasc), verapamil (Calan, Isoptin, Covera, Verelan), diltiazem (Cardizem)
    • Vasodilators such as doxazosin (Cardura), prazosin (Minipress), terazosin (Hytrin), clonidine (Catapres), hydralazine (Bidil, Hydra-Zide), minoxidil

This is not a complete list of drug interactions. Ask your doctor or pharmacist for more information.

Invokamet Precautions

Serious side effects have been reported with Invokamet including the following:

  • Lactic acidosis. Tell your healthcare provider right away if you have some or all of the following symptoms of lactic acidosis:
    • Feeling very weak, tired, or uncomfortable
    • Unusual muscle pain
    • Trouble breathing
    • Unusual or unexpected stomach discomfort
    • Feeling cold
    • Feeling dizzy or lightheaded
    • Suddenly developing a slow or irregular heartbeat
  • Hypoglycemia (low blood sugar). Tell your healthcare provider right away if you have some or all of the following symptoms of low blood sugar:
    • Feeling shaky
    • Feeling nervous
    • Sweating
    • Feeling cold or clammy
    • Confusion
    • Fast or irregular heart rate
  • Genital fungal infections (yeast infections). Tell your healthcare provider right away if you have some or all of the following symptoms of a yeast infection:
    • Abnormal vaginal discharge. Vaginal discharge can range from slightly watery to thick/chunky and white.
    • Burning or itching of the vagina
    • Pain while urinating or peeing
    • Pain during intercourse or sex
    • Redness of the skin around the vagina
  • High levels of potassium in your blood (hyperkalemia). Tell your healthcare provider right away if you have some or all of the following symptoms of having high levels of potassium in your blood:
    • Muscle weakness
    • Irregular heart rhythm
    • Nausea
    • Suddenly collapsing
  • Low blood pressure (hypotension). Tell your healthcare provider right away if you have some or all of the following symptoms of low blood pressure:
    • Tiredness
    • Feeling lightheaded, especially when standing up
    • Dizziness
    • Nausea
  • Low levels of Vitamin B12. Tell your healthcare provider right away if you have some or all of the following symptoms of having low levels of vitamin B12:
    • Wanting to eat ice or items that are not food
    • Feeling extremely tired or fatigue
    • No desire to eat or no appetite
    • Diarrhea or constipation
    • Having pale skin
    • Having difficulty concentrating
    • Shortness of breath
    • Having a swollen tongue
    • Having gums that are bleeding
  • bone fractures. Patients taking Invokamet are at an increased risk of bone fractures. In addition, this medication may decrease bone mineral density.

Do not take Invokamet if you:

  • are allergic to Invokamet or to any of its ingredients 
  • have kidney damage
  • have acute or chronic metabolic acidosis
  • are undergoing radiologic exams where contrast dye is used

Invokamet Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Invokamet, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking Invokamet, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to Invokamet or to any of its ingredients
  • have kidney problems
  • have liver problems
  • have heart failure
  • drink alcohol
  • are dehydrated
  • are undergoing radiologic studies where contrast dyes are used
  • are pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Invokamet and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Invokamet falls into category C. No studies have been done in animals, and no well-controlled studies have been done in pregnant women. Invokamet should be given to a pregnant woman only if clearly needed.

Invokamet and Lactation

Tell your doctor if you are breastfeeding or plan to breastfeed.

Metformin has been detected in human breast milk, but canagliflozin is not known if it crosses into human breast milk. Because of the possibility for adverse reactions in nursing infants from Invokamet, a choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered.

Invokamet Usage

Take Invokamet exactly as prescribed.

Invokamet comes in a tablet form and is taken twice a day.

Take this medication with food. 

If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Invokamet at the same time.

Invokamet Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • the condition being treated
  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication
  • your weight
  • your height
  • your age
  • your gender

The recommended dose of Invokamet for the treatment of Type 2 Diabetes is 50 mg canagliflozin/500 mg metformin twice a day. The maximum dose of Invokamet for the treatment of Type 2 Diabetes is 150 mg canagliflozin/1000 mg metformin twice a day.

Invokamet Overdose

If you take too much Invokamet, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

If Invokamet is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Other Requirements

  • Store Invokamet at room temperature.
  • Keep this and all medicines out of the reach of children.

Invokamet FDA Warning

WARNING: LACTIC ACIDOSIS

  • Lactic acidosis is a rare but serious complication that can occur due to metformin accumulation. The risk increases with conditions such as renal impairment, sepsis, dehydration, excess alcohol intake, hepatic impairment, and acute congestive heart failure.
  • The onset is often subtle, accompanied only by nonspecific symptoms such as malaise, myalgias, respiratory distress, increasing somnolence, and nonspecific abdominal distress.
  • Laboratory abnormalities include low pH, increased anion gap, and elevated blood lactate.
  • If lactic acidosis is suspected, Invokamet should be discontinued and the patient hospitalized immediately