Repaglinide and Metformin

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Repaglinide/metformin treats Type 2 Diabetes. May cause nausea. Take with food to help with nausea.

Repaglinide and Metformin Overview

Reviewed: January 23, 2015

Repaglinide/metformin is a prescription medication used to treat Type 2 Diabetes.

It is a single product containing 2 medications: repaglinide and metformin. Repaglinide belongs to a group of drugs called meglitinides, or simply glinides. It works by stimulating the pancreas to release more insulin which will help lower blood sugars. Metformin belongs to a group of drugs called biguanides. It works by reducing the amount of sugar that the liver produces. 

This medication comes in a tablet form and is usually given 2 to 3 times a day with meals. Common side effects of repaglinide/metformin include headaches, low blood sugars, nausea, and diarrhea. 

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Repaglinide and Metformin Drug Class

Repaglinide and Metformin is part of the drug class:

Repaglinide and Metformin FDA Warning

Lactic acidosis is a rare but serious complication that can occur due to metformin accumulation. The risk increases with conditions such as sepsis, dehydration, excess alcohol intake, hepatic impairment, renal impairment, and acute congestive heart failure.

The onset of lactic acidosis often is subtle, and accompanied only by nonspecific symptoms such as malaise, myalgias, respiratory distress, increasing somnolence, and nonspecific abdominal distress.

Laboratory abnormalities include low pH, increased anion gap and elevated blood lactate.

If acidosis is suspected, repaglinide/metformin should be discontinued and the patient hospitalized immediately