Rhofade

Rhofade is a prescription medication used to treat facial redness associated with rosacea in adults. Rhofade is part of a group of drugs called alpha1A agonists that work to narrow the blood vessels in the skin and decrease redness. 

Rhofade comes as a cream and is applied topically to the entire face 1 time a day. 

Common side effects of Rhofade include skin inflammation or swelling, worsening of rosacea symptoms, and skin itching. 

Rhofade is a prescription medication used to treat facial redness associated with rosacea in adults. Rosacea is a skin disorder that causes redness and pimples on the face. 

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information. 

• Allergan, Inc.

Serious side effects have been reported with Rhofade. See the “Rhofade Precautions” section.

Common side effects of Rhofade include the following:

• skin inflammation and swelling
• worsening rosacea symptoms
• skin itching
• skin redness
• pain where applied

This is not a complete list of Rhofade side effects. Ask your doctor or pharmacist for more information. Tell your doctor if you have any side effects that bother you or that do not go away. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

• medications that effect blood pressure such as benazepril (Lotensin, Lotensin HCT), captopril (Capoten, Capozide), enalapril (Vasotec, Vaseretic), fosinopril (Monopril, Monopril HCT), lisinopril (Prinivil, Prinzide, Zestril, Zestoretic), moexipril (Univasc, Uniretic), quinapril (Accupril, Accuretic, Quinaretic), ramipril (Altace), trandolapril (Mavik, Tarka), azilsartan (Edarbi), candesartan (Atacand), irbesartan (Avapro), losartan (Cozaar), olmesartan (Benicar), telmisartan (Micardis, Twynsta), valsartan (Diovan), metoprolol (Toprol XL, Lopressor), carvedilol (Coreg), bisoprolol (Zebeta), betaxolol (Kerlone), nebivolol (Bystolic), propranolol (Inderal)
• monoamine oxidase inhibitors such as tranylcypromine (Parnate), phenelzine (Nardil), selegiline (Eldepryl, Zelapar), isocarboxazid (Marplan), and rasagiline (Azilect)

This is not a complete list of Rhofade drug interactions. Ask your doctor or pharmacist for more information.

Serious side effects have been reported with Rhofade including the following:

Changes in blood pressure. Rhofade should be used with caution in patients with heart disease. Call your doctor if you experience any of the following symptoms:

• dizziness
• sweating
• vomiting
• fatigue
• chest pain
• shortness of breath
• racing heartbeat

Decreased blood flow to the hands, arms, feet, and legs. Call your doctor if you experience any of the following symptoms:

• numbness in your hands, arms, feet, or legs
• muscle pain
• pale or blue skin
• tingling
• loss of ability to sense temperature

Risk of Angle Closure Glaucoma. Risk for patients with narrow-angle glaucoma. Rhofade should be used with caution in narrow-angle glaucoma patients. 

Do not use Rhofade if you are allergic to Rhofade or to any of its ingredients. 

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Rhofade, there are no specific foods that you must exclude from your diet when receiving this medication.

Before taking Rhofade, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

• are allergic to Rhofade or to any of its ingredients
• have or have had high or low blood pressure
• have or have had Raynaud's disease
• have or have had glaucoma
• are pregnant or plan to become pregnant
• are breastfeeding or plan to breastfeed

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Tell your doctor if you are pregnant or plan to become pregnant.

There are no well-done studies that have been done in humans with Rhofade. In animal studies, pregnant animals were given this medication, and the babies did not show any medical issues related to this medication.

Tell your doctor if you are breastfeeding or plan to breastfeed.

Rhofade has been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from Rhofade, a choice should be made whether to stop nursing or to stop the use of this medication. The importance of the drug to the mother should be considered.

Take Rhofade exactly as prescribed.

Rhofade comes as a cream and a thin layer is applied topically to the entire face 1 time a day. Do not apply Rhofade to areas of the skin that are irritated or broken.

The Rhofade pump should be primed before the first use. Wash your hands immediately following Rhofade application.

If you miss a dose, apply the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and apply your next dose at the regular time. Do not apply double the amount of Rhofade at one time.

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

There is no specific dosing for Rhofade, but you should apply a thin layer of the cream for a max number of 1 time per day.

If you apply too much Rhofade, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away. 

Store Rhofade at room temperature. Keep Rhofade and all medications out of the reach of children.