7 Common Questions About Restless Legs Syndrome

Yes, some cold and allergy medications with antihistamines — such as Benadryl — have been known to worsen symptoms. Other medications that have been linked to worsening RLS symptoms include:

• Medications for dizziness and nausea such as meclizine, Compazine, Phenergan and Reglan
• Antidepressants like Elavil, Prozac, Lexapro and Effexor
• Psychiatric medications like haloperidol and phenothiazines, which are used to treat bipolar disorders, schizophrenia and other serious mental health issues.

Always talk to your doctor before stopping any medications.